RapamycinFungusV1, Main, Exploration, bibRecord, 000151

Annexin V expression on CD4+ T cells with regulatory function.

Identifieur interne : 000151 ( Main/Exploration ); précédent : 000150; suivant : 000152

Annexin V expression on CD4+ T cells with regulatory function.

Auteurs : Anna-Lena Bollinger [Suisse] ; Thomas Bollinger [Suisse] ; Jan Rupp [Allemagne] ; Kensuke Shima [Allemagne] ; Natalie Gross [Allemagne] ; Laura Padayachy [Suisse] ; Rachel Chicheportiche [Suisse] ; Gisella L. Puga Yung [Suisse] ; Jörg Dieter Seebach [Suisse]

Source :

Immunology [ 1365-2567 ] ; 2020.

RBID : pubmed:31642515

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Annexin A5 (genetics), Annexin A5 (immunology), Annexin A5 (metabolism), Cell Adhesion (MeSH), Cell Proliferation (MeSH), Cells, Cultured (MeSH), Cytokines (immunology), Cytokines (metabolism), Disease Models, Animal (MeSH), Endothelial Cells (immunology), Endothelial Cells (metabolism), Humans (MeSH), Hypersensitivity, Delayed (genetics), Hypersensitivity, Delayed (immunology), Hypersensitivity, Delayed (metabolism), Lymphocyte Activation (MeSH), Male (MeSH), Mice, Inbred C57BL (MeSH), Phenotype (MeSH), Phosphatidylserines (metabolism), Phosphorylation (MeSH), Signal Transduction (MeSH), T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (metabolism), TOR Serine-Threonine Kinases (metabolism), Th1 Cells (immunology), Th1 Cells (metabolism).
MESH :
- chemical , genetics : Annexin A5.
- chemical , immunology : Annexin A5, Cytokines.
- chemical , metabolism : Annexin A5, Cytokines, Phosphatidylserines, TOR Serine-Threonine Kinases.
- genetics : Hypersensitivity, Delayed.
- immunology : Endothelial Cells, Hypersensitivity, Delayed, T-Lymphocytes, Regulatory, Th1 Cells.
- metabolism : Endothelial Cells, Hypersensitivity, Delayed, T-Lymphocytes, Regulatory, Th1 Cells.
- Animals, Cell Adhesion, Cell Proliferation, Cells, Cultured, Disease Models, Animal, Humans, Lymphocyte Activation, Male, Mice, Inbred C57BL, Phenotype, Phosphorylation, Signal Transduction.

Abstract

Regulatory T (Treg) cells induce immunologic tolerance by suppressing effector functions of conventional lymphocytes in the periphery. On the other hand, immune silencing is mediated by recognition of phosphatidylserine (PS) on apoptotic cells by phagocytes. Here we describe expression of the PS-binding protein Annexin V (ANXA5) in CD4⁺ CD25^hi Treg cells at the mRNA and protein levels. CD4⁺ ANXA5⁺ T cells constitute about 0·1%-0·6% of peripheral blood CD3⁺ T cells, exhibit co-expression of several Treg markers, such as Forkhead box P3, programmed cell death protein-1, cytotoxic T-lymphocyte antigen-4 and CD38. In vitro, ANXA5⁺ Treg cells showed enhanced adhesion to PS⁺ endothelial cells. Stimulated by anti-CD3 and PS⁺ syngeneic antigen-presenting cells CD4⁺ ANXA5⁺ T cells expanded in the absence of exogenous interleukin-2. CD4⁺ ANXA5⁺ T cells suppressed CD4⁺ ANXA5^- T-cell proliferation and mammalian target of rapamycin phosphorylation, partially dependent on cell contact. CD4⁺ ANXA5⁺ T-cell-mediated suppression was allo-specific and accompanied by an increased production of anti-inflammatory mediators. In vivo, using a model of delayed type hypersensitivity, murine CD4⁺ ANXA5⁺ T cells inhibited T helper type 1 responses. In conclusion, we report for the first time expression of ANXA5 on a subset of Treg cells that might bridge classical regulatory Treg function with immune silencing.

DOI: 10.1111/imm.13140
PubMed: 31642515
PubMed Central: PMC6954731

Affiliations:

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Annexin A5 (genetics)</term>
<term>Annexin A5 (immunology)</term>
<term>Annexin A5 (metabolism)</term>
<term>Cell Adhesion (MeSH)</term>
<term>Cell Proliferation (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Cytokines (immunology)</term>
<term>Cytokines (metabolism)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Endothelial Cells (immunology)</term>
<term>Endothelial Cells (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Hypersensitivity, Delayed (genetics)</term>
<term>Hypersensitivity, Delayed (immunology)</term>
<term>Hypersensitivity, Delayed (metabolism)</term>
<term>Lymphocyte Activation (MeSH)</term>
<term>Male (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Phenotype (MeSH)</term>
<term>Phosphatidylserines (metabolism)</term>
<term>Phosphorylation (MeSH)</term>
<term>Signal Transduction (MeSH)</term>
<term>T-Lymphocytes, Regulatory (immunology)</term>
<term>T-Lymphocytes, Regulatory (metabolism)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Th1 Cells (immunology)</term>
<term>Th1 Cells (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (MeSH)</term>
<term>Adhérence cellulaire (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Annexine A5 (génétique)</term>
<term>Annexine A5 (immunologie)</term>
<term>Annexine A5 (métabolisme)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cellules endothéliales (immunologie)</term>
<term>Cellules endothéliales (métabolisme)</term>
<term>Cytokines (immunologie)</term>
<term>Cytokines (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Hypersensibilité retardée (génétique)</term>
<term>Hypersensibilité retardée (immunologie)</term>
<term>Hypersensibilité retardée (métabolisme)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
<term>Lymphocytes T régulateurs (métabolisme)</term>
<term>Lymphocytes auxiliaires Th1 (immunologie)</term>
<term>Lymphocytes auxiliaires Th1 (métabolisme)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Phosphatidylsérine (métabolisme)</term>
<term>Phosphorylation (MeSH)</term>
<term>Phénotype (MeSH)</term>
<term>Prolifération cellulaire (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Annexin A5</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Annexin A5</term>
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Annexin A5</term>
<term>Cytokines</term>
<term>Phosphatidylserines</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hypersensitivity, Delayed</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Annexine A5</term>
<term>Hypersensibilité retardée</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Annexine A5</term>
<term>Cellules endothéliales</term>
<term>Cytokines</term>
<term>Hypersensibilité retardée</term>
<term>Lymphocytes T régulateurs</term>
<term>Lymphocytes auxiliaires Th1</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Endothelial Cells</term>
<term>Hypersensitivity, Delayed</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th1 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term>
<term>Hypersensitivity, Delayed</term>
<term>T-Lymphocytes, Regulatory</term>
<term>Th1 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Annexine A5</term>
<term>Cellules endothéliales</term>
<term>Cytokines</term>
<term>Hypersensibilité retardée</term>
<term>Lymphocytes T régulateurs</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Phosphatidylsérine</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Adhesion</term>
<term>Cell Proliferation</term>
<term>Cells, Cultured</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Phenotype</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Adhérence cellulaire</term>
<term>Animaux</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Phosphorylation</term>
<term>Phénotype</term>
<term>Prolifération cellulaire</term>
<term>Souris de lignée C57BL</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Regulatory T (Treg) cells induce immunologic tolerance by suppressing effector functions of conventional lymphocytes in the periphery. On the other hand, immune silencing is mediated by recognition of phosphatidylserine (PS) on apoptotic cells by phagocytes. Here we describe expression of the PS-binding protein Annexin V (ANXA5) in CD4<sup>+</sup>
  CD25<sup>hi</sup>
 Treg cells at the mRNA and protein levels. CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells constitute about 0·1%-0·6% of peripheral blood CD3<sup>+</sup>
 T cells, exhibit co-expression of several Treg markers, such as Forkhead box P3, programmed cell death protein-1, cytotoxic T-lymphocyte antigen-4 and CD38. In vitro, ANXA5<sup>+</sup>
 Treg cells showed enhanced adhesion to PS<sup>+</sup>
 endothelial cells. Stimulated by anti-CD3 and PS<sup>+</sup>
 syngeneic antigen-presenting cells CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells expanded in the absence of exogenous interleukin-2. CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells suppressed CD4<sup>+</sup>
  ANXA5<sup>-</sup>
 T-cell proliferation and mammalian target of rapamycin phosphorylation, partially dependent on cell contact. CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T-cell-mediated suppression was allo-specific and accompanied by an increased production of anti-inflammatory mediators. In vivo, using a model of delayed type hypersensitivity, murine CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells inhibited T helper type 1 responses. In conclusion, we report for the first time expression of ANXA5 on a subset of Treg cells that might bridge classical regulatory Treg function with immune silencing.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31642515</PMID>
<DateCompleted><Year>2020</Year>
<Month>02</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2567</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>159</Volume>
<Issue>2</Issue>
<PubDate><Year>2020</Year>
<Month>02</Month>
</PubDate>
</JournalIssue>
<Title>Immunology</Title>
<ISOAbbreviation>Immunology</ISOAbbreviation>
</Journal>
<ArticleTitle>Annexin V expression on CD4<sup>+</sup>
 T cells with regulatory function.</ArticleTitle>
<Pagination><MedlinePgn>205-220</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/imm.13140</ELocationID>
<Abstract><AbstractText>Regulatory T (Treg) cells induce immunologic tolerance by suppressing effector functions of conventional lymphocytes in the periphery. On the other hand, immune silencing is mediated by recognition of phosphatidylserine (PS) on apoptotic cells by phagocytes. Here we describe expression of the PS-binding protein Annexin V (ANXA5) in CD4<sup>+</sup>
  CD25<sup>hi</sup>
 Treg cells at the mRNA and protein levels. CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells constitute about 0·1%-0·6% of peripheral blood CD3<sup>+</sup>
 T cells, exhibit co-expression of several Treg markers, such as Forkhead box P3, programmed cell death protein-1, cytotoxic T-lymphocyte antigen-4 and CD38. In vitro, ANXA5<sup>+</sup>
 Treg cells showed enhanced adhesion to PS<sup>+</sup>
 endothelial cells. Stimulated by anti-CD3 and PS<sup>+</sup>
 syngeneic antigen-presenting cells CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells expanded in the absence of exogenous interleukin-2. CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells suppressed CD4<sup>+</sup>
  ANXA5<sup>-</sup>
 T-cell proliferation and mammalian target of rapamycin phosphorylation, partially dependent on cell contact. CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T-cell-mediated suppression was allo-specific and accompanied by an increased production of anti-inflammatory mediators. In vivo, using a model of delayed type hypersensitivity, murine CD4<sup>+</sup>
  ANXA5<sup>+</sup>
 T cells inhibited T helper type 1 responses. In conclusion, we report for the first time expression of ANXA5 on a subset of Treg cells that might bridge classical regulatory Treg function with immune silencing.</AbstractText>
<CopyrightInformation>© 2019 John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bollinger</LastName>
<ForeName>Anna-Lena</ForeName>
<Initials>AL</Initials>
<Identifier Source="ORCID">0000-0003-0100-1227</Identifier>
<AffiliationInfo><Affiliation>Division of Immunology and Allergology, Department of Medicine, University Hospitals and Medical Faculty, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bollinger</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0003-2842-9610</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Geneva, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rupp</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000-0001-8722-1233</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shima</LastName>
<ForeName>Kensuke</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">0000-0002-5357-4230</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gross</LastName>
<ForeName>Natalie</ForeName>
<Initials>N</Initials>
<Identifier Source="ORCID">0000-0003-0773-3285</Identifier>
<AffiliationInfo><Affiliation>Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Padayachy</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Division of Immunology and Allergology, Department of Medicine, University Hospitals and Medical Faculty, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chicheportiche</LastName>
<ForeName>Rachel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Division of Immunology and Allergology, Department of Medicine, University Hospitals and Medical Faculty, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Puga Yung</LastName>
<ForeName>Gisella L</ForeName>
<Initials>GL</Initials>
<Identifier Source="ORCID">0000-0002-2283-7798</Identifier>
<AffiliationInfo><Affiliation>Division of Immunology and Allergology, Department of Medicine, University Hospitals and Medical Faculty, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seebach</LastName>
<ForeName>Jörg Dieter</ForeName>
<Initials>JD</Initials>
<Identifier Source="ORCID">0000-0001-5748-4577</Identifier>
<AffiliationInfo><Affiliation>Division of Immunology and Allergology, Department of Medicine, University Hospitals and Medical Faculty, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>11</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Immunology</MedlineTA>
<NlmUniqueID>0374672</NlmUniqueID>
<ISSNLinking>0019-2805</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000632306">ANXA5 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017304">Annexin A5</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000627124">Anxa5 protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010718">Phosphatidylserines</NameOfSubstance>
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<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D017304" MajorTopicYN="N">Annexin A5</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002448" MajorTopicYN="N">Cell Adhesion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
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</MeshHeading>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006968" MajorTopicYN="N">Hypersensitivity, Delayed</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008213" MajorTopicYN="Y">Lymphocyte Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010718" MajorTopicYN="N">Phosphatidylserines</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
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<MeshHeading><DescriptorName UI="D018417" MajorTopicYN="N">Th1 Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Immunity. 2007 Oct;27(4):635-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17919943</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(9):e45234</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23028866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2008 May 30;133(5):775-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18510923</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2008 Sep;28(17):5288-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18573870</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Immunol. 2014 Feb 11;5:46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24575095</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Nov 2;294(5544):1102-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11691993</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2013 Sep 1;191(5):2351-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23904169</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Immunol. 1989 Nov;9(6):437-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2698397</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2001 Apr 1;15(7):807-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11297505</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2002 May 9;417(6885):182-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12000961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2006 Aug;25(2):195-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16920638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Immunol. 2012;30:531-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22224781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2016 Jun;23(6):952-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26891692</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 1999 May 19;258(3):713-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10329451</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1992 Sep 5;267(25):17907-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1387643</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2007 Jun 11;204(6):1257-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17502665</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13837-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16945916</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Dec 10;279(50):52623-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15381697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Rheumatol. 2013 Oct;9(10):595-603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23958797</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transplantation. 2007 Aug 15;84(3):392-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17700166</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thromb Haemost. 1995 Feb;73(2):172-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7792726</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Allergy Clin Immunol. 2010 Aug;126(2):280-9, 289.e1-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20624644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2003 May;11(5):1151-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12769841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2000 Oct;7(10):911-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11279536</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 2005 Mar 1;44(8):2833-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15723527</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Apr 30;8(4):e62449</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23638088</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1986 Jul 11;233(4760):203-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3523754</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Autoimmun. 2013 Sep;45:49-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23849743</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1990 Nov 26;275(1-2):15-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2148156</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 1997 Jul 17;337(3):154-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9219701</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Immunol. 2002 Nov 18;1(1):2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12459040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunotoxicol. 2009 Dec;6(4):209-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19908939</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int Immunol. 2008 Feb;20(2):247-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18156623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Pharmacol. 1989 Aug;97(4):1051-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2529014</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2014 May;259(1):173-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24712466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Immunol. 2018 May;79(5):294-303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29288698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2005 Feb;12(2):194-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15540112</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2004 Nov 1;200(9):1157-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15504819</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Chim Acta. 2014 Jan 1;427:42-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24121031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1992 Feb 18;31(6):1886-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1310621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2007 Dec;27(6):927-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18082433</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2014 Jun 18;6(241):241ra78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24944193</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 1989 Nov 1;263(3):929-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2532007</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2010 Mar 5;140(5):619-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20211132</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care Med. 2014 Jan;42(1):e32-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24145837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2005 Jun;6(6):449-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15928709</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochemistry. 1988 Sep 6;27(18):6645-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2973805</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cold Spring Harb Perspect Med. 2013 Nov 01;3(11):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24186492</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2015 Jun 1;194(11):5233-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25917090</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2007 Dec 14;131(6):1124-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18083102</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2009 May;30(5):636-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19464986</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Sep 28;287(40):33733-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22879587</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Exp Med Biol. 2017;981:351-385</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29594868</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Endocrinol Metab. 2014 Mar;99(3):932-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24423325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2006 Dec 15;108(13):4094-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16912227</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Cell Res. 2006 Apr 1;312(6):719-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16380116</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO Rep. 2011 Apr;12(4):358-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21399623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood Coagul Fibrinolysis. 1992 Feb;3(1):11-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1623112</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2007 Nov 15;450(7168):435-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17960135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2010 Jul;236:219-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20636820</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2007 Nov 15;450(7168):430-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17960134</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2008 Apr 18;283(16):10593-600</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18230608</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2005 Feb 15;174(4):1783-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15699103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transfus Apher Sci. 2017 Aug;56(4):612-625</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28803708</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1997 Nov 27;390(6658):350-1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9389474</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1995 Aug 1;155(3):1151-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7636184</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Immunol. 2011 May;41(5):1249-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21469093</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2002 Jul 15;196(2):255-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12119350</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2007 Aug;7(8):585-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17653126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1997 Nov 21;272(47):29411-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9367994</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2719-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7681987</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2011 Oct 28;35(4):445-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22035837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2004 Nov;21(5):604-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15539147</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1988 Jan;7(1):21-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3258820</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 1996 Mar 1;97(5):1204-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8636431</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2004 Jun 1;103(11):4216-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14976053</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Chem Hoppe Seyler. 1990 May;371(5):383-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2143074</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Suisse</li>
</country>
<region><li>Canton de Genève</li>
</region>
<settlement><li>Genève</li>
</settlement>
<orgName><li>Université de Genève</li>
</orgName>
</list>
<tree><country name="Suisse"><noRegion><name sortKey="Bollinger, Anna Lena" sort="Bollinger, Anna Lena" uniqKey="Bollinger A" first="Anna-Lena" last="Bollinger">Anna-Lena Bollinger</name>
</noRegion>
<name sortKey="Bollinger, Thomas" sort="Bollinger, Thomas" uniqKey="Bollinger T" first="Thomas" last="Bollinger">Thomas Bollinger</name>
<name sortKey="Chicheportiche, Rachel" sort="Chicheportiche, Rachel" uniqKey="Chicheportiche R" first="Rachel" last="Chicheportiche">Rachel Chicheportiche</name>
<name sortKey="Padayachy, Laura" sort="Padayachy, Laura" uniqKey="Padayachy L" first="Laura" last="Padayachy">Laura Padayachy</name>
<name sortKey="Puga Yung, Gisella L" sort="Puga Yung, Gisella L" uniqKey="Puga Yung G" first="Gisella L" last="Puga Yung">Gisella L. Puga Yung</name>
<name sortKey="Seebach, Jorg Dieter" sort="Seebach, Jorg Dieter" uniqKey="Seebach J" first="Jörg Dieter" last="Seebach">Jörg Dieter Seebach</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Rupp, Jan" sort="Rupp, Jan" uniqKey="Rupp J" first="Jan" last="Rupp">Jan Rupp</name>
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<name sortKey="Gross, Natalie" sort="Gross, Natalie" uniqKey="Gross N" first="Natalie" last="Gross">Natalie Gross</name>
<name sortKey="Shima, Kensuke" sort="Shima, Kensuke" uniqKey="Shima K" first="Kensuke" last="Shima">Kensuke Shima</name>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Annexin V expression on CD4+ T cells with regulatory function.

Annexin V expression on CD4+ T cells with regulatory function.

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